Regulating ENaC’s gate

ENaCs and ASICs as therapeutic targets.

The epithelial Na(+) channel (ENaC) and acid-sensitive ion channel (ASIC) branches of the ENaC/degenerin superfamily of cation channels have drawn increasing attention as potential therapeutic targets in a variety of diseases and conditions. Originally thought to be solely expressed in fluid absorptive epithelia and in neurons, it has become apparent that members of this family exhibit nearly u...

Characterization of HyNaCs - peptide-gated DEG/ENaCs from Hydra magnipapillata

The Kinematics of Emission-line Galaxies in Clusters from Enacs

By using the ENACS data, we have studied the properties of emission-line galaxies (ELG) in clusters. The fraction of ELG in clusters is 16 %; this fraction is slightly dependent on the cluster velocity dispersion, being larger for \colder" systems. ELG tend to occur more frequently than other cluster galaxies in substructures. However, only a minor cluster fraction has an ELG population with a ...

What Gate? Gate what?

Since economic liberalization period, Chinese housing typologies have experienced a dramatical change. From the traditional Siheyuan building type to the current gated communities, which prototype has become the most widespread residential housing type in modern China Cities. At the same time, many negative feedbacks about the city life have been appearing, such as traffic congestion, the loss ...

SK channels gate information processing in vivo by regulating an intrinsic bursting mechanism seen in vitro.

Understanding the mechanistic substrates of neural computations that lead to behavior remains a fundamental problem in neuroscience. In particular, the contributions of intrinsic neural properties such as burst firing and dendritic morphology to the processing of behaviorally relevant sensory input have received much interest recently. Pyramidal cells within the electrosensory lateral line lobe...